Some people expressed a "Not care" attitude about the size of your opponents stack when deciding to play "interesting" hands. This is all my thinking from discussions with Fluxor and my own suppositions. Your interesting hands are only going to hit so often so you want to make sure when they do you are in a hand that matters. If I am playing 100/NL against guys with $25 stacks I do not want to get HU against them with my 24h. Who cares? So what if I stack them? They are scum under my heals and only keep me from my true goal of stacking the guys who have equal stacks to me. If my longshot hand hits I want to be fully paid off.